In recent years, potential precursors of gallbladder carcinoma have been identified, making their recognition by diagnosticians clinically relevant. Gallbladders are common surgical specimens and most procedures are performed for cholecystitis and cholelithiasis. Hence based upon the above literature findings the present study was planned to assess the clinical profile of the Gallstones. The present study was planned on 50 cases of any age and either gender with gall stones. The patients were referred to Department of Surgery in IGIMS, Patna from Dec 2007 to Jun 2008. All sonographically diagnosed patients of gallstone admitted into the department. Clinical presentation like pain, vomiting, dyspepsia, fever and preoperative ultrasound findings of all patients were noted on predesigned performa. Gallbladder is a rare identity with silent progression thus present in advanced stage carrying high rate of mortality and morbidity. It is more common in female than in male. Presence of gallstone has higher risk of malignancy. The present study concludes that femininity and obesity are strongly associated with gallstones formation presumably due to excess cholesterol in bile which eventuates in cholecystectomy.