Background: Grip strength is a measure of muscular fitness and is related to many health problems in adults. The purpose of this study was to examine the independent relationship that sociodemographic predictors have on grip strength in U.S. adults. Methods: Data for this research came from adults 20+ years of age participating in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Grip strength (kg) was measured three different times in each hand using a handgrip dynamometer and the largest reading across all trials served as the participant’s score. Sociodemographic variables consisted of age, income, education, race/ethnicity, and marital/partner status. Sex-specific multiple linear regression models were employed to examine the independent relationship between predictors and grip strength. Results: In bivariate analyses, significant (ps<.05) differences in grip strength were noticed within all sociodemographic variables. Linear trends in grip strength were seen across age (indirect) and income (direct) for both sexes and across education (direct) in females. In multivariate models, all sociodemographic predictors (except education for males) were significantly related to grip strength in both males (F=208.2, R²=0.24, SE=8.1 kg, p<.001) and females (F=95.3, R²=0.28, SE=5.2 kg, p<.001). Conclusion: Results from this study indicate that sociodemographic characteristics are related to grip strength in U.S. adults and account for approximately a quarter of its variance.