Present study was conducted to compare the clinical efficacy of propofol alone with propofol ketamine combination during ambulatory anesthesia. Hospital Based study wich is a randomized double blinded study was conducted in 80 patients in the department of anaesthesiology VCSGGMS & Research Institute, Garhwal, over a period of about 2 yrs. Patients belonging to ASA I & II, aged between 20-40 yrs, 40 in each group was taken. Group P: Propofol alone Group PK: Propofol ketamine combination. Induction doses, pulse rate, oxygen saturation, systolic, diastolic blood pressure, mean arterial pressure and complication if any were recorded. The parameter were subjected to T test analysis and found statistically significant difference in induction dose, systolic, diastolic, mean arterial pressure & complication.