Malaria is still a deadly disease in Gowa, South Sulawesi. this is evidenced by the increase in cases of Malaria. One of the emergence of malaria outbreaks due to weather changes. Various methods used to overcome this disease are by avoiding malaria mosquito bites is the most important way to prevent malaria transmission, such as using mosquito nets, the absence of puddles, and using repellent lotion.The purpose was to get an overview of Malaria cases regarding climate change during season transition in the Gowa District Health Office.The data obtained from the reports of Malaria cases in the Gowa DHO area in 2017. Cross sectional study design was used. Malaria incidence by 87 cases. The peak incidence occurs enhancer malaria occur in March and June, respectively 81 and 80 cases. Trend incidence of malaria in Gowa volatile. significantly increased cases per three months. There is a transition effect of the weather with increased cases of malaria in the region of Gowa district health offices, so we need a place to the breeding prevention and vector surveillance.