Objective: This study aimed to determine the possible effects of cell phones on apoptosis in colon, stomach, and liver tissues and the protective role of vitamins C and E against these effects. Method: Two same-model and same-mark cell phones were used, one in stand-by mode and the other in calling mode. A total of 42 male Wistar albino rats were used in the study. The rats were divided into six groups: control, antioxidant, call, stand-by, call + antioxidant, and stand-by + antioxidant. Apoptosis indexes were studied as pathological indicators. Results: Statistically significant apoptosis was observed only in the call-mode group in stomach tissue. The beneficial effects of antioxidants were observed only in the stand-by group in liver tissue. Conclusions: People should be careful about the biologic effects of cell phones, especially in the calling mode. Antioxidants (vitamins C and E) can help get rid of the harmful effects of radiofrequency waves.