Background: H1N1 is pandemic today and our country and state are also being affected by this disease. This disease spreads through respiratory tract (coughing and sneezing).Medical students remain at a higher risk of acquiring the disease. So this study was conducted to educate and sensitize the medical students regarding the spread of the disease and its prevention that will help indirectly to reduce panic, morbidity and mortality regarding this disease. Objectives: (1) to assess knowledge of study subjects regarding H1N1 spread and prevention. (2) To educate the study subjects on H1N1 disease and its prevention. (3) To assess the knowledge of study subjects after educational intervention. Material and Methods: This was a cross sectional study, carried out during October-December 2017 among, 227 medical under graduate students of Gandhi Medical College Bhopal. MS Excel and Epi info version 6 was used for statistical analysis. Study population was interviewed through pre-tested and pre-designed questionnaire and intervention in the form of Audio visual presentations was given. Results: Out of 227 students who took part in the study, 91.9% were aware of the causative agent of swine flu and it rise up to 99.1% post intervention.67% of the participants were aware of the transmission of the disease and 43% were aware of the symptoms. Conclusion: The present study shows the need for medical students to have accurate and adequate information about communicable diseases like swine flu. The study revealed that the knowledge on this is average and suboptimal in few aspects like symptomatology.