Acute meningoencephalitis presenting with seizure and altered sensorium is a common presentation seen in tropical countries like India, etiology of which ranges from bacterial, viral, fungal or mycobacterial meningoencephalitis. However, such sinister and life threatening diagnosis is seldom expected in patients who are stable and present to Out Patient Department (OPD) with only a single complaint of headache. We report a 39 year old man who presented with headache and was diagnosed with intracranial cryptococcosis with no cause of immunosuppression.