Nephrotic-range proteinuria is the loss of 3 grams or more per day of protein into the urine or, on a single spot urine collection, the presence of 2 g of protein per gram of urine creatinine. Nephrotic syndrome is the combination of nephrotic-range proteinuria with a low serum albumin level and edema. Lipoproteins play an important role in the transport of plasma lipids; their increase or alteration in various fractions may be responsible for hypercholesterolemia, in nephrotic syndrome. Hence based on above literature findings the present study was planned to evaluate the derangement of serum lipids in nephrotic syndrome Childs. The 80 child patients were enrolled From Upgraded Department of Paediatrics in Patna Medical College and Hospital, Patna from Jan 2017 to Oct 2017 in to the present study. The 80 childrens were divided in two groups as control and cases. The group I consist of 40 patients as normal patients and group II patients has 40 patients suffered from nephrotic syndrome. Hence from above study it can be concluded that the positive relationship between the serum lipid profile and the nephrotic syndrome. Bases on these findings we therefore advocate that lipid profile should be among the biochemical investigations included for any nephritic syndrome patient for better management.