Most patients who undergo surgical procedures experience acute postoperative pain, but evidence suggests that less than half report adequate postoperative pain relief. Many preoperative, intraoperative, and postoperative interventions and management strategies are available for reducing and managing postoperative pain. Hence based on the literature findings the current study was planned to evaluate the post-operative pain by administration of opioid analgesics, Morphine, Butorphanol and Fentanyl along with local Anaesthetic Bupivacaine, when given epidurally. The 40 patients admitted to Department of Surgery and referred to department of Anaesthesia in IMS BHU, Varanasi from Jan 2016 to July 2016 for the epidural anaesthesia were included in the present study. The patients undergoing lower abdominal surgery and suitable for the epidural anaesthesia were included in the study. From the above studies it can be conclude that Morphine or Butorphanol along with Bupivacaine can be safely given epidurally to obtain effective post-operative analgesia after lower abdominal surgeries. The duration of sedation is seen maximum in morphine administered patients. The Butorphanoladministered patients observed immediate onset of sedation. The maximum number of patients had seen the nausea and vomiting side effects in morphine group patients. In Bupivacaine administered patients are observed with hypotension as side effects prominently.