This study was done to compare the efficacy of drotaverine hydrochloride and hyoscine butyl bromide in first stage of labour. The prospective randomized control trail was done to understand the effects of drotaverine and hyoscine in cervical dilatation and thus duration of first stage of labour. Study evaluated the side effect profit of both the drug and overall patient acceptance of the two. The study population of 300 patients was divided into three groups. One group was given injection Drotaverine 1 amp iv single dose, second was given injection Hyoscine butylbromide 1 amp iv single dose in active phase of labour, and the third group did not receive any anti-spasmodic. Periodic evaluation of cervix, uterine contractions a foetal heart sounds were done for each complaint of the patients was noted. Approximate blood less in third stage of labour was noted. In this research topic, each group was further subdivided into nulliparous and multiparous, and all the main outcome measures were calculated for each such group. The ages of patients in all three groups in both nulliparous and multiparous patients are comparable. The dilatation on admission of patients in all three groups of both nulliparous and multiparous patients are comparable. All three groups of both nulliparous and multiparous patients are comparable in terms of dilatation at injection or detection of active phase.