Background: Chronic tonsillitis (CT)-adenoid hypertrophy (AH) is the most common cause of obstructive sleep apnea (OSA), which is one of the most common reasons of nocturnal hypoxia in children. Aims and objective: To evaluate MPV in patients diagnosis with adenoid hypertrophy (AH) and/or chronic tonsillitis. Materials and Methods: Fifty patients (Case group) who underwent adenoidectomy or adenotonsillectomy with a diagnosis of adenoid hypertrophy (AH) and/or chronic tonsillitis were studied in Department of Otorhinolaryngology & Head and Neck Surgery at Gandhi Medical College and Hamidia Hospital from March, 2015 and August, 2016 and compared with age-matched 50 healthy controls subjects (Control group). Detailed clinical history was recorded for all the patients followed by thorough ENT examination. Confirmation was done using rigid nasal endoscopy and fiber optic flexible endoscopy (FOFE). Mean platelet volume (MPV) were individually assessed. Results: Majority of the patients belong to the age group of 6-10 years (38%). Male preponderance (56% vs. 54% in cases and control respectively) was observed in present study. MPV was significantly higher among cases (11.26±1.12) as compared to control group (7.74±0.59) (p=0.032). Among cases mean MPV (11.59±0.63) was highest among patients belonging to age group of 2-10 years. MPV among males and females in case cohort was 10.72±1.23 and 10.86±1.14 respectively whereas MPV among female and male of control group was 7.76±0.52 and 7.73±0.49 respectively. No significant difference between MPV of males and females within cases and controls cohort was obtained. Among females, MPV was significantly higher in cases (10.72±1.23) as compared to Control (7.76±0.52) (p=0.012) similarly males in case group (10.86±1.14) had significantly higher MPV as compared to control (7.73±0.49) (p=0.008). Conclusion: ATH was more prevalent in children who were in first decade of life and males patient. MPV was higher in female children with ATH.