India has a growing trend of acute myocardial infarction (AMI) due to shifting lifestyle. Objective:To evaluate the mortality in patients with AMI and to find its clinical risk correlates. Methods: This study was conducted on 126 consecutive AMI cases admitted in the tertiary care centre in south india. During inpatients management, outcomes were followed up from admission till discharge or expiry. Results:Of the total 126 cases, majority (55.55%) had Inferior wall MI; mean age of 12 deaths was 58.01 ± 13.60. Maximum patients belonged to the age group of 56 to 65 years (38.4%). Reportedly 83.10% had some physical activities; 16.52% were vegetarian; 40.5% were smokers; 34.6% had family history of AMI, 64.3% were diabetics; and 21.4% were hypertensives. Lifestyle-related risk factors, physical activity, and vegetarian diet were not protective; family history and addiction to smoking were significantly associated with AMI deaths. Revascularization with primary PCI led to less mortality as compared to thrombolysis (p value 0.046). Conclusions:Acute STEMI had male and middle-age predominance with mortality being associated with family history, smoking, diabetes, and hypertension.