A fever can be caused by many medical conditions ranging from non-serious to life threatening. This includes viral, bacterial and parasitic infections such as the common cold, urinary tract infections, meningitis, malaria and appendicitis among others. Non-infectious causes include vasculitis, deep vein thrombosis, side effects of medication, and cancer among others. The aim the present study was to find out the clinical profile, cause and complications associated with the patients admitted with the fever. The study has planned in Department of General medicine, VMMC & Safdarjung Hospital, New Delhi. The 50 patients detected with malaria were enrolled in to the study. The age group of the patients are below 10 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All the patients are informed consents. The entire patient’s clinical history was collected. From the above data generated it can be concluded that the fever with thrombocytopenia reveals among infections dengue and malaria are common causes because of seasonaland regional variations.