The studies in paediatric populations indicated that the problem of discharge against medical advice (DAMA) is more prevalent in neonates. This has serious consequences considering limited physiological reserve of the neonates. These studies also indicated that reasons for DAMA vary according to settings, culture, and other factors. So, the present study was planned to know the knowledge about spectrum of neonatal factors and proper management of common neonatal problems will lead to better outcome and improved quality of life among survivors. The 50 neonates were enrolled From Upgraded Department of Pediatrics, Patna Medical College & Hospital, Patna from Dec 2017 to Oct 2018 in the present study. This was a retrospective descriptive study from NICU of a teaching hospital were included. After obtaining approval from the Institutional Ethics Committee (IEC), necessary permissions were taken from the hospital authorities. The outcome of the hospital stay was 42 cases were discharged, 3 were referred to other hospital. There are 4 cases of DAMA and 1 cases of death in the patients admitted to NICU. Hence from the present study it can be conclude that Neonatal jaundice, preterm and low birth weight babies had significantly high mortality even with standard intensive care. Maternal and neonatal health care policies should be further strengthened for prevention of complications related to birth. The present study showed the various aspects of the patients admitted to the NICU and the discharge against the medical advice cases.