The microorganisms are responsible for the generation of the acids which lead to the demineralization and weakening of the enamel. Hence based on these findings the present study was planned to demonstrate the effect of the mouthwash on Dental remineralization. The data from the 3 study group were collected and presented as below. The enamel were administered with the Sensodyne Pronamel Daily Mouthwash, listerine Advanced Defence Cavity Guard and no Mouthwash. The chips were subjected to 6 hours of demineralization. At the end of each application, samples were detached from the retainer for micro hardness measurements consisting individual micro hardness indentation measurements in Knoop units. From the data generated in the above mouthwash application on the enamel it is concluded that the applied mouthwash achieves the comparable remineralisation. This will helpful in the selection of mouthwash for the different enamels. The studies above are the initial evidence to encourage further exploration into the philosophy of multiple mechanisms acting together for caries prevention.