The primary outcome of the study was to measure the incidence of Post-Operative Sore throat at 4 h post‑operatively in adult patients undergoing surgery of duration of up to 1 h under GA. The secondary outcomes included the incidence and severity of post-operative sore throat at immediate recovery, and post‑operatively, evaluation of side‑effects including nausea, vomiting, cough and dry mouth in both the groups. The data from the 40 patients undergoing general anaesthesia were evaluated for the post-operative sore throat. The patients recruited for the study were kept fasted for 6 h preceding surgery. On arrival at the operating room, patients were monitored by electrocardiogram, non-invasive blood pressure and pulse oximetry (SpO2). Anaesthesia protocol was made uniform for all patients. Group I received a saline nebulisation 5.0 ml and Group II received ketamine 50 mg (1.0 ml) (with 4.0 ml of the saline) nebulisation. The data is collected and presented as below. Hence from the present study it can be concluded that the use of pre‑operative ketamine nebulisation reduced the incidence and severity of POST during early post‑operative period in patients receiving GA with tracheal intubation.