Osteoporosis is considered to be one of the most prevalent skeletal disorders worldwide, caused by an imbalance in the body’s calcium leading to decreased bone density. It is diagnosed by dual energy x-ray absorptiometry. It usually occurs in the elderly population, especially postmenopausal women. The Management focuses on lifestyle modification and decreasing the risk of falls and thereby the risk of fractures. The first line of medical treatment is Bisphosphonate. Osteoporosis is a multifactorial disorder that has genetic, hormonal and environmental factors. There are many drugs that contribute to the development of osteoporosis. Researches reviewed in this article on proton pump inhibitors were found to have different results on their effect in bone mass density. To this day, there is no strong definitive evidence attributing osteoporosis to proton pump inhibitors.