This study was planned out to find out the consequences of oral aspirin in decreasing the frequency of post-operative myalgia triggered by supervision of suxamethonium and to relate it with precurarization (with pancuronium) and with a control group of patients.

The group I patients were precurarised by giving injection pancuronium 0.01 mg/kg body weight intravenously three minutes before commencement of induction of anaesthesia. This group of patients showed 7 cases without fasciculation, 3 cases of mild fasciculation. The group II patients were administered with soluble aspirin (tablet Disprin) 600 mg orally one hour before induction of the anaesthesia. This group of patients had only one patient without fasciculation. 6 patient’s showed mild fasciculation, 2 with moderate fasciculation and 1 case with severe fasciculation. In control group of patients 1 case was observed with no fasciculation, 5 cases with mild fasciculation, 2 cases with moderate and 2 severe cases of fasciculation.

Hence the data revealed that the Preoperative aspirin 600mg orally 1 hr before operation effectively reduces Suxamethonium induced pain and avoid complications associated with pretreatment with non-depolarising agents. This is helpful to avoid the side effects arises due to Suxamethonium.