Acute phase proteins (APPs) are blood proteins primarily synthesised by hepatocytes as part of the acute phase response. The acute phase response is a non-specific and complex reaction of an organism, triggered by different stimuli including injury, trauma, infection, stress, inflammation, as well as neoplasia. It comprises a wide variety of behavioural, physiological, biochemical and nutritional changes. The liver diseases contain the liver cirrohosis, jaundice, infective hepatitis. 30 normal healthy groups were also selected as control to study the levels of acute phase proteins in them. Ceruloplasmin and Serum transferrin is estimated from the pathological findings. The present study was planned in the Department of Biochemistry in Viswabharathi Medical College. From the above study it can be concluded that the acute phase proteins in liver disorders plays important role. Evaluation of bio-chemical parameters not only predicts the decompensating but also increases the scope of early diagnosis, prognosis, and therapy there by reducing the mortality and morbidity of cirrhosis.