Objective: The purpose of this literature review was to evaluate intramedullary (IM) nailing as a technique for clavicle fracture fixation as compared to traditional plate fixation. Methods: A search of the current literature was performed, leading to the inclusion of 38 suitable papers for analysis. A search on EMbase conducted using the search items “intramedullary nail” and “clavicle” was performed. The outcomes of these papers were used to outline a better understanding of the role of IM nailing in the treatment of displaced clavicle fractures, especially those involving the midshaft of the bone. Results/Discussions: Each fixation method is not without complication, but both modalities can be used successfully in a range of settings, when operative management is pursued. Surgeon preference and expertise largely dictates the choice of treatment for displaced midshaft clavicle fractures. Conclusion: From this systematic review, it is possible to suggest that both intramedullary fixation and plate fixation have very positive results in terms of shoulder function scores, as well as time to union.