Pregnancy is an isolated risk factor for thromboembolic disease, but when combined with thrombophilia, the results can be very serious. A 23-year-old pregnant woman admitted for intestinal pseudo-obstruction. Radiological investigations showed superior mesenteric vein (SMV) thrombosis which quickly evolved towards a mesenteric venous infarction. Etiological assay results showed a deficit in protein C. The evolution towards death despite the rapidity of management is evidence of the seriousness of this pathology, especially when there is a complete obstruction of the SMV. Thrombophilia test is often positive in this context.