Background: Neck pain is very common in the region of the upper trapezius muscle. Highest prevalence is seen in middle aged groups. Women are more affected than men. Objective: To assess the effectiveness of classical strain/counterstrain technique with ultrasound therapy and myofascial release technique with ultrasound therapy to reduce pain and to improve cervical lateral flexion ROM on subjects with trigger point pain in unilateral upper trapezius. Design: Randomized comparative parallel open label study Materials and Method: 60 participants with upper trapezius trigger points of both the sex were randomly divided into group A and group B, 30 in each group. Group A was treated with classical strain/counterstrain technique with ultrasound therapy and Group B was treated with myofascial release technique with ultrasound therapy for 5days continuously 1 session per day. Patients were evaluated with VAS, NDI scores and CROM on day 1 and day 5. Result: Efficacy of Classical strain/counterstrain technique with ultrasound therapy was more effective in relieving pain, improving functional ability and increase in ROM. Conclusion: Classical Strain/counterstrain technique with ultrasound therapy was significant than Myofascial release technique with ultrasound therapy in patients with unilateral trigger point of upper trapezius.