The use of IV Paracetamol or IV Diclofenac as analgesia, using an opioid as rescue analgesic only when needed, would reduce the amount of opioid used and ensure a comfortable postoperative recovery period. Hence the proposed study was thus piloted to compare the effects of Paracetamol and Diclofenac as peri operative analgesic in laparoscopic cholecystectomy. The patients were divided in two study groups as Group A & Group B. In Group A were administered IV Paracetamol 1 mg/kg (maximum 1g in 100ml infusion) over 15-20 minutes, 30 min prior to the end of surgery was administered. In group B IV Diclofenac sodium 2mg/kg maximum 75 mg in 100 ml of normal saline 30 minutes prior to the end of surgery was administered. The data generated from the above study it can be concluded that Paracetamol infusion provides better and prolonged analgesia with low pain scores and lesser requirement for rescue analgesia compared to Diclofenac.