Preeclampsia, hypertensive disorder of pregnancy is characterized by hypertension, proteinuria occurring following the 20^th week of gestation in previously normotensive pregnant women. Though many scientific clinical and biochemical tests have been anticipated for prediction of preeclampsia there is not enough substantiation for their use in clinical practice. Emerging novel strategies like targeting the CSE/H2S activity, role of marinobufagenin in the development of hypertension, have been investigated only in animal models of preeclampsia. Further research, requiring clinical trials may provide some evidence for their use as a part of the treatment strategies. Keeping in mind, the possible drawbacks with respect to the current investigative procedures, this review highlights on how the altered level of plasma thiols i.e. elevated cysteine, homocysteine, cysteinylglycine and decreased glutathione levels and increased serum CRP levels in subjects with abnormal doppler (proneness to preeclampsia) could be used as risk marker to predict preeclampsia. This review additionally highlighted on how L-Arginine administration in subjects with abnormal doppler decreased the plasma thiols and serum CRP levels back to their existing normal range in a normotensive pregnant woman. Endothelial dysfunction could be associated with the presence of raised concentrations of CRP and plasma thiols that alters the production and degradation of Nitric oxide.