Acne is a common skin condition that affects different areas in body including face and neck. Acne vulgaris is very prevalent among teenagers and it affects also adults but in lower percent. Acne is treatable condition, treatment of acne can be topical or systemic, however management of acne seems to be not good. Aim: To assess knowledge and practice of primary healthcare physicians for management of Acne Vulgaris in Sudair area. Method: This is a cross sectional study which was conducted in Sudair region, Saudi Arabia on physicians who work at primary health care centers. Pre-tested questionnaire was used to assess knowledge and practice as well as demographics of physicians. Results: 49% pf physicians had good knowledge, 44% had moderate knowledge and 7% had poor knowledge, while 72% of physicians and 28% had poor and good practice respectively. Practice was significantly associated with age (P-value=0.03). Conclusion:There was a lack in knowledge and poor practice among physicians regarding management of acne vulgaris in Sudiar area.