Introduction: Cholelithiasis is one of the major cause of mortality and morbidity especially in females. Mucosal alterations in gall bladder are associated with stones. Aims and objectives: Present study was planned to evaluate histopathological changes in cholecystectomy specimens and their correlation with presence and type of stones. Material and methods: A total of 432 cholecystectomy specimens sent for histopathological examination were included in the study. Association with age, sex, mucosal changes, presence or absence of stones, type and number of stones were seen. Results: Male to female ratio was 1:6 with major age group was between 31 -40 years. Premalignant and malignant lesions were associated with females and increased age. Mixed type of stones were most commonly found and also were associated with premalignant and malignant lesions. Conclusion: All cholecystectomy specimens should be thoroughly examined for various mucosal alterations and also if stones found should be properly evaluated for number and type.