Fire is boon for mankind when under control, becomes catastrophic when uncontrolled; the root of mightiest disasters mankind would have ever witnessed claiming innumerable lives. In cases of severe burns the mortality has rapidly decreased in last few decades. Still even today sepsis remains major cause of mortality in burn patients. All patients who are admitted in the burn ICU have reserved prognosis and are subjected to various complications. The survival rate is significantly impaired in elderly as compared to younger patients due to age associated immune dysfunction. Hence based on the above findings the current study was planned to evaluate the prognostic factors for prediction of complications and outcomes in burn patients. The present study was planned in the Department of Plastic Surgery in Patna Medical College and Hospital, Patna, Bihar. Total 10 cases of the burns patients admitted to the hospital were enrolled in the present study. The patients with First and second degree burns, Total burns surface area of 40% - 90%, Admissions within 24 hours of incidence were evaluated for the present findings. Diet consisted of high protein with balanced carbohydrate and fat diet to provide high calorie diet. In the first 48 h no antibiotic was given for small area burns (<10% TBSA) For large area burns with inhalation burns-on admission intravenous antibiotics were given are Cefotaxim/amoxicillin-clavulanic acid Amikacin. The data generated from the present study suggest that Poor outcome in burn patients was seen to be related to persistently low serum cholesterol, high serum triglyceride and presence of echinocytes, toxic granules, toxic vacuoles. Simple and easy to analyse prognostic factors will be greatly helpful for doctors, as well as valuable for experienced clinicians. In many parts of world where most of the burn victims belong to low socio economic status, these early mortality indicators based on routine investigations will prove to be cost effective as they can help the clinician to explain the course of disease within few days, and help relatives to take decisions regarding continuation or termination of treatment as per the prognosis and their financial circumstances.