An orally disintegrating tablet (ODT) is a drug dosage form available for a limited range of over-the counter (OTC) and prescription medications. Orally disintegrating tablets differ from the traditional tablets, in that they are designed to be dissolved on the tongue rather than swallowed whole. This article quotes the advantages of orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received ever increasing demand and this particular field has become a rapidly growing area in the pharmaceutical industry. By introducing into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water. When ODTs are put on tongue they disintegrate instantly, releasing the drug which dissolve or disperse in the saliva fluid. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down in the stomach. In such cases, bioavailability of the drug is significantly greater than those observed from the conventional tablet dosage form. The advantages of the mouth dissolving dosage form are increasingly being recognized in both, industry and academia. Their growing importance has been underlined recently when European Pharmacopoeia adopted the term “Oro-dispersible Tablet” as tablet that is to be place in the mouth where it disperses rapidly before swallowing. ODTs have some challenges and if we implement the use of herbal ingredients in that it would be more challenging but solutions to overcome these challenges were shown in this paper.