The colon is the most common site of gastrointestinal lipomas. Colonic lipoma is the second most common benign colonic tumor, next to adenoma in prevalence. The majorities of lipomas are asymptomatic and are often incidental findings. Lipoma of the decending colon is rare and could pose a diagnostic dilemma. We present a case of huge symptomatic lipoma of the decending colon mimicking subacute appendicitis. CT abdomen is an indispensable tool for diagnosis and familiarity with CT imaging findings may be helpful in making an accurate diagnosis.