The nephrotic syndrome is a clinical syndrome complex characterized by a number of renal and extrarenal features. The main aim of the present study was to evaluate the recent changes in the epidemiology and histopathological profile of the disease causing Nephrotic syndrome. Methods: The study was conducted on 44 patients who were presented with the nephritic syndrome. Results: Of the 44 patients studied FSGS and MCD were the more commonest nephrotic syndrome. The symptoms like microhematuria, oliguria, hypertension, hypoalbuminemia, renal failure, anemia and hyperlipidemia were seen in the patients affected with nephrotic syndrome. Further, the clinicopathological correlation was present in 59.1% of patients. Conclusion: Thus, IgA nephropathy and Minimal change disease were the most common histopathological subtypes.