Aim: To compare hemodynamic response to IV dexmedetomidine and IV clonidine in spine surgery under general anaesthesia. Material and method: This prospective randomized comparative study of haemodynamic response of IV Dexmedetomidine and IV Clonidine in spine surgery under general anaesthesia was conducted in the Department of Anaesthesiology & Critical Care in Sher - i - Kashmir Institute of Medical Sciences. Study was approved by Institutional Medical Ethical Committee and written informed consent was obtained from all Patient participating in the study. 60 patients of either sex, between 18-55yrs of age of ASA Grade 1&2 undergoing spine surgery under general anaesthesia were enrolled in this study and patients were randomly assigned into two groups i.e. Group D (30) and Group C (30). Haemodynamic responses were compared in both groups by measuring HR, SBP, DBP, MAP, RR, SPO2. Results: Fall in mean HR and MAP was more in group D than that of group C which was statistically highly significant. There was no significant changes in mean RR of Group D and also in Group C which was statistically not significant (P=0.348). Saturation was maintained to 100% throughout the procedure. Conclusion: From this study it was concluded that intravenous dexmedetomidine causes better maintenance of haemodynamic parameter as when compared with clonidine.