Aim: To evaluate the cardiovascular manifestations in patients suffering from hepatitis C via 2D-Echocardiography. Materials and methods: The present prospective observational study was conducted for 2 years among 100 patients in the post graduate department of Medicine at Chhatrapati Shivaji Subharti Hospital. All HCV seropositive patients were included in the present study. Blood samples were obtained from each participant using disposable needles and vacuum syringes. The serum samples were fractionated within 6 hours after collection and stored at -70°C until assay. The LA size, LVEDD size, RA Size, RV Size, LV Ejection Fraction, E/A Ratio, RA/RV Ratio, IVS Diameter, VPW Diameter and Pericardial Effusion were recorded with the help of 2D/M-mode/CD Echocardiography. Results: Total bilirubin and SGOT was raised among 22% and 78% of the patients. Further, SGPT was raised in 88% of the patients. There was a significant difference in the left atrial size and left ventricular dimension from that of normal subjects. 26 patients included in our study group showed evidence of LV systolic dysfunction. 3 and 4 out of 100 patients in the study group were found to have RA dilatation and RV dilatation, respectively. 11 out of 100 patients of the study group were found to have dilated cardiomyopathy. The prevalence of E/A <1 was 25%. Conclusion: The results of present study concluded that chronic hepatitis C is likely to lead to an increase in Left atrial size and left ventricular end diastolic dimension. Independent risk of dilated cardiomyopathy is possible in patients with chronic hepatitis C.