DUB can occur during lifespan of a woman at any time from menarche, occasionally even after the menopause in ovulatory and anovulatory cycles. This condition has enormous consequences with regard to social life, morbidity, and clinical load. DUB can be classified into primary, secondary and iatrogenic groups. Primary DUB is due to dysfunction arising in the hypothalamopitutary-ovarian axis or dysfunction in the endometrium itself. Secondary DUB is due to endocrinopathies, hematological, vascular disease, liver disorders. Iatrogenic DUB is caused by drugs, exogenous hormone administration, and intrauterine contraceptive devices. So DUB is a diagnosis of exclusion; and one should proceed through logical stepwise evaluation to rule out all other causes of abnormal uterine bleeding. Management of DUB is not complete without tissue diagnosis especially in perimenopause and postmenopause. It has been known to be associated with almost any type of endometrium, even apparently normal endometrium like proliferative and secretory type. Some other histology of endometrium in DUB are irregular ripening, irregular shedding, atrophy, hyperplasia and carcinoma. Many a times the clinical and intra operative diagnosis does not correlate with histopathological diagnosis. Hence the present study was planned for clinical assessment of the dysfunctional uterine bleeding in female patients in Bihar region. The present study was planned in Department of Obstetrics and Gynaecology, Lord Buddha Koshi Medical College and Hospital, Saharsa, Bihar, India. Total 25 cases of the patients attending the Gynaecological outpatient department with dysfunctional uterine bleeding complete history was taken with regard to age, parity, socioeconomic status, history of bleeding from other sites, pattern of menstrual irregularity i.e. age at menarche, type, duration, amount of blood loss and associated pain, any other gynaecological co-morbidity, previous hormone treatment if any and any previous endocrine problem. Medical illness and pelvic pathology were ruled out clinically. Pap smear was done. The data generated from the present study concludes that histopathological study of endometrium in females with abnormal uterine bleeding plays an important role in diagnosing various histological patterns and aetiopathological factors. Hence histopathological examination is mandatory, in cases of peri-menopausal and postmenopausal abnormal uterine bleeding.