Hemostasis is a dynamic process in which the platelet and the blood vessels play a key role. Platelets also mediate leukocyte movement from the blood stream through the vessel wall to tissues and are capable of forming reactive oxygen species and the oxidative stress that accompanies inflammation can also activate platelets. Platelets ability to influence other cells indicates that they can also play many principle roles in the pathophysiology of diseases. Platelet indices, are a group of derived platelet parameters, obtained as a part of the automatic complete blood count. Emerging evidence suggests that Platelet indices may have diagnostic and prognostic value in certain diseases. Hence, simultaneous measurement of platelet indices (MPV, PDW, P-LCR) will provide a valid instrument for measuring disease. The present study was done in Department of General Medicine, Patna Medical College and Hospital from Oct 2016 to Feb 2017. This study was aimed to investigate the relation between sepsis and platelets and its indices (MPV, PDW, P-LCR). Total 50 patients were included, out of that 25 cases of Sepsis were enrolled in study group and 25 cases of the normal patients were enrolled as control cases. Platelet distribution width is an important index in platelet parameters. It along with other platelet indices can give valuable information regarding the mechanism of platelet destruction. Increased variation in Platelet Distribution Width indicates greater platelet heterogenicity along with destruction and splenic pooling. PDW varies inversely with platelet count.