Early diagnosis, meticulous selection of the patients who are liable for resection and referral of these patients to specialized centres, can improve the short and long-term outcome. For a better selection of the patients that may have the benefits of surgery and postoperative adjuvant therapy, we should assess the risk factors that can affect the outcome. Most of the studies reported these prognostic factors for survival after resection of PDAC, like the age of the patients at the time of surgery, one or more co-morbidity, tumor size and stage, pathological grade of the tumor, the presence of positive lymph nodes (LNs), the surgical margin of resection etc. The aim of this study was to analyze the clinical outcome and the potential prognostic factors that may affect survival after PD for PDAC. The present study was planned in Department of Gastrointestinal Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar. The 25 cases of the Pancreaticoduodenectomy (PD) were enrolled in the present study. The study was conducted from Jan 2018 to Nov 2018. The diagnosis of pancreatic ductal adenocarcinoma (PDAC) was done by histopathological study of the specimen after surgery. Other pathology after PD or other periampullary adenocarcinoma were excluded from the present study. The data generated from the present study concludes that High tumor marker CA19-9, tumor size, and grade are significant risk factors for poor survival after resection of PDAC and should be taken into account in the selection of patients for surgery to improve the outcome. Familiarity with normal anatomical findings is essential to distinguish expected post-operative changes from surgical complications or recurrent disease.