Introduction: Platelet-rich plasma (PRP) uses injections of a concentration of a patient’s own platelets to accelerate the healing of injured tendons, ligaments, muscles and joints. Corticosteroids (also known as steroids) are medicines that can be used to treat inflammation. De Quervain’s disease is a painful condition that affects the tendons sheath of first extensor compartment in your wrist. It occurs when the 2 tendons of first compartment around the base of your thumb become swollen. Objective: To compare the efficacy of PRP injection versus corticosteroid injection for de Quervain’s disease. Materials and method: 25 male and 35 female (Mean Age 35.2 yrs.) presenting with de Quervain’s disease where randomized to receive there PRP injection (1ml PRP with 1ml of 2% xylocaine) given by a single surgeon. Patients were assessed before (Days 0) and after (Days 15, 30, 60) treatment for wrist pain and function and grip strength. Patients where follow up 1 yr. to assess wrist pain over the radial styloid process. Result: In the present study of 60 patients there were 25 male and 35 female. In the present study of 60 patients the mean age was 35.2 years (Range between 15 to 55 years). Infection, tendon rupture and neurovascular damage where not found. Five patient reported pain for unto 3 days after PRP injection. In both groups grip strength improved dramatically after treatment, but the mode of improvement different. Compared with PRP injection. corticosteroid injection improve at a faster rate over the first 15 days and then started to decline slightly until 60 day. After PRP injection pain, function and grip strength improve steadily and where eventually better. PRP injection and Corticosteroid injection 30 days and faster rate 60 days of both group P-Value 0.0001. Almost high grater rate 30 days Group comparison with pain, function and grip strength patients. Conclusion: PRP was more effective over the long term follow up period then corticosteroid injection in improving pain, function and grip strength. That's way we recommend this in a first line injection treatment because it is very simple, cheap and more effective.