Nowadays, Thoracic epidural anaesthesia is one of the most common anaesthesia technique used to conduct elective open cholecystectomy among all methods. As regional anaesthetic technique provides intraoperative anaesthesia as well as excellent post-operative analgesia without systemic side effects. But only limiting factor is duration of block. Several combinations of LAs and adjuvants such as tramadol, sufentanyl, clonidine, and fentanyl have been employed in the search for near ideal agent, which remains elusive. Alpha 2 – adrenoceptor agonists prolong the duration of sensory and motor block with local anaesthetics. Most of clinical studies about the intrathecal Alpha-2 adrenoceptor agonists are related to Clonidine. Dexmedetomidine is eight times more selective Alpha-2 adrenoceptor agonist emerging as a valuable adjunct to regional anaesthesia and analgesic. Hence from the present finding the present study was planned for Comparative Evaluation of Dexmedetomidine and Clonidine in epidural Anesthesia in Females Admitted to PMCH. The present study was planned in Department of Anesthesia, Patna Medical College and Hospital, Patna, Bihar. The study was conducted from July 2017 to June 2018. The 30 females undergoing the vaginal hysterectomies were enrolled in the present study. The 15 cases were enrolled in the Group A administered with the Ropivacaine & Dexmedetomidine for epidural anesthesia. The another 15 females were administered with the Ropivacaine & Clonidine. The data generated from the present study concludes that dexmedetomidine is a better adjuvant than clonidine in epidural anaesthesia as far as patient comfort, stable cardio-respiratory parameters, intraoperative and post-operative analgesia is concerned. Overall the experience with dexmedetomidine was quite satisfactory as compared to clonidine because of its superior sedative and anxiolytic properties during the surgical procedure under regional anaesthesia.