Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin ^[1]. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine ^[1]. Slow growth may occur in children. Hence based on above findings the present study was planned for Assessment of Liver Function Profile in Children's Diagnosed with Thalassemia Receiving Multiple Blood Transfusions. The present study was planned in Department of Pediatrics, Darbhanga Medical College & Hospital, Laheraisarai, Bihar, India, during the period of April 2019 to September 2019.Total 20 cases of childrens between 1-15 years of age, who are diagnosed to have Thalassemia are included in the study. The data generated from the present study concludes that in hepatitis seronegative thalassemic patients, regular blood transfusion along with iron chelation therapy helps in maintaining liver function and decreasing iron overload in liver. It is also recommended that Liver function test should be done regularly at 3 months interval to detect any hepatic dysfunction.