A hypothesis suggests a possible role for prostaglandins and cyclooxygenases in Succinlycholine induced myalgia. Pre-treatment with a prostaglandin inhibitor is effective in reducing the incidence of myalgia. Succinylcholine induced myalgia increases length of stay in hospital thereby increasing the cost of treatment. Therefore prevention of myalgia is very important. Various agents have been attempted to decrease the postoperative muscle pain namely, Non-depolarising neuromuscular blockers, NSAIDS, benzodiazepines, phenytoin, ketorolac, vitamin E derivatives, local anaesthetics. Hence based on above findings the present study was planned for Assessment of Comparison of Effect of Oral Aspirin and Intravenous Diazepam on Succinylcholine Induced Postoperative Myalgia. Total 30 patients undergoing the elective surgery under general anaesthesia were enrolled in the present study. The patients divided in two study groups as 15 patients in each group. The patients were administered with the oral aspirin and intravenous diazepam on succinylcholine induced postoperative myalgia. The present study was planned in Department of Anesthesia and Critical Care, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India. The study was conducted from the duration of February 2018 to Nov 2018. Postoperatively all the patients were assessed for myalgia. Myalgia was defined as “muscle pain not related to surgical intervention”. The data generated from the present study concludes that oral aspirin prevents succinylcholine induced myalgia more effectively than intravenous diazepam. Prevention of succinylcholine induced myalgia is most important and various methods have been used to prevent the same.