Early recovery and extubation in the operating room is the preferred method when the pre-operative state of consciousness is relatively normal and surgery does not involve critical brain areas or extensive manipulation. In the complicated or unstable patient, the risks of early extubation may outweigh the benefits. Patients with increased intracranial pressure (ICP) are prone to severe cardiac and or cerebral complications following emergence from general anesthesia and during the recovery period. Hence the present study was planned to evaluate the effect of dexmedetomidine on hemodynamic responses during tracheal extubation. The present study was planned in Department of Anesthesia, Nalanda Medical College and Hospital, Patna, Bihar. Total 30 Patients were enrolled in the present study. The 15 patients were enrolled in Group I as cases and 15 patients were enrolled as control patients in Group II. Group I patients received 0.5 μg/kg inj. dexmedetomidine in 100 ml normal saline slow IV infusion over 10 minutes and Group II patients received 100 ml normal saline IV infusion over a period of 10 minutes. Study drugs were given at the time of skin closure. Patients were kept nil orally for 6 hours before procedure. All patients were uniformly premeditated with inj. glycopyrrolate 0.2 mg IM 30 minutes before shifting to operation theatre. The data generated from the present study concludes that use of dexmedetomidine before extubation attenuates the hemodynamic response to extubation. It enables smooth extubation of the trachea and provides adequate sedation postoperatively. Dexmedetomidine increases the incidence of bradycardia and hypotension, but does not cause side effects like respiratory depression, laryngospasm, bronchospasm, undue sedation and desaturation.