Objective: To evaluate the analgesic and antipyretic activities of alcoholic extract of Justicia neesii Ramam. Materials and Methods: The peripheral analgesic activity of Justicia neesii Ramam (200 and 400 mg/kg) was studied using hot-plate method in rats. The antipyretic activity was studied in Brewer’s yeast-induced pyrexia. Results: Justicia neesii Ramam significantly increased the reaction time in hot-plate test. It also showed significant antipyretic activity in Brewer’s yeast-induced pyrexia in rats throughout the observation period of 3 h (p≤0.05) respectively. Conclusion: the present study demonstrates that Justicia neesii Ramam has marked antipyretic and moderate analgesic activities.