Chronic kidney disease (CKD) affects approximately 13.6% of adults in India, is associated with a substantially increased risk of death and cardiovascular events and accounts for a disproportionately large burden on Medicare’s financial resources. The increasing prevalence of CKD in the community cannot be fully explained by trends in known risk factors such as diabetes mellitus and hypertension, suggesting that other factors may contribute to the disease process. Medications may be a potential factor, particularly given trends towards polypharmacy. Identifying iatrogenic risk factors for CKD may help to promote the rational use of medications and reduce the burden of CKD worldwide. Proton Pimp Inhibitors are one of the most prescribed medicine even in India. Chronic use of PPI precipitates Hyponetremia, Hyperkalaemia, reduced Glomerular Filtration Rate and finally renal damage to some extent. In this present study a positive correlation is observed between chronic use of PPI and occurrence of AKD, as proved by estimations of relevant biochemical parameters.