Effects of low doses of ketamine on intracranial pressure in patients having space occupying lesion of the brain
Tauqeer anjum mir, Sheikh Ubaid Ahmad, Zaid Bin Muneer
Aim: To analyse the effects of low doses of ketamine on intracranial pressure in patients having space occupying lesion of the brain. Material and Method: The present hospital based, observational, experimental study was conducted in the Department of Anaesthesiology & Critical Care in Sher - i - Kashmir Institute of Medical Sciences. This study includes all patients undergoing neurosurgery for space occupying lesion of the brain during the study period. Selected patients were divided into 3 groups i.e. Group A (Placebo), Group B (0.25 mg/kg of ketamine) and Group C (0.5 mg/kg of ketamine). After given of IV drugs all 3 group patients were intubated with appropriate size endotracheal tube, 1% propofol infusion @ 50-200 mcg/kg/hr was stared just after intubation and patients were ventilated with 50% O2, 50% air for next 5 mins. Results: There was little increase in HR (bpm) among the three groups after post-tracheal intubation at two and five minutes. According to the criteria used in the present study, ICP values decreases approximately similar in group B and C, while it decreased at 2 min in group A and increased again to previous values after 5min. Conclusion: In patients with space occupying lesion undergoing mechanical ventilation, ketamine effectively decreased ICP and prevented untoward ICP elevations during potentially distressing interventions, without lowering blood pressure.
Tauqeer anjum mir, Sheikh Ubaid Ahmad, Zaid Bin Muneer. Effects of low doses of ketamine on intracranial pressure in patients having space occupying lesion of the brain. International Journal of Medical and Health Research, Volume 5, Issue 3, 2019, Pages 220-223