Chronic renal failure (CRF) is a chronic, progressive, irreversible condition which causes much suffering to the patient. The families, societies and country have to bear a great economic burden to manage patients of CRF. Significant electrophysiological changes may be present in nerve conduction studies (NCS) of peripheral nerves of chronic renal failure patients having no clinical neuropathy. This was a Cross-sectional comparative type of study. The study period extends from January 1, 2007 to December 31, 2007. the study was carried out in the out-patient and indoor patients of Nephrology and Medicine units of Rajshahi Medical College Hospital (RMCH), Bangladesh. The study aimed to evaluate the Status of sensory nerve conduction parameters in patients with CRF. In CRF there is progressive, irreversible loss of renal function, which render the patient permanently dependent upon renal replacement therapy. Peripheral neuropathy adds more to these problem and patients gradually develop weakness. The quality of life deteriorates and finally the patient may become bedridden. The management of these problems are long term and costly. Due to poverty CRF patients become a burden for the family and for the society. Majority of these patients are unable to bear the expenditure of renal replacement therapy. Early detection of neuropathy in CRF patients is one of the management of strategy of these patients because timely intervention may reduce the morbidity related to neuropathy. In CRF patients who have no clinical signs or symptoms of neuropathy, nerve conduction studies can detect early abnormalities. So, this study was designed to find out the subclinical peripheral neuropathy in CRF patients in our country. If subclinical neuropathy can be detected early and appropriate treatment instituted, it reduces further progression of neuropathy and also reduce neuropathy related complications. Such type of study has not been conducted in our country previously so this study will provide some data about the prevailing condition in our country and future researchers can carry out further studies on this subject.