Meningitis is an infection of the meninges, the membranes that protect the spinal cord and the brain. When the meninges become infected, they start to swell, putting pressure on the spinal cord or brain and causing potentially life-threatening complications. Meningitis is called an acute condition because symptoms strike quickly and suddenly. Hence the present study was planned to assess the Incidence of Meningitis in neonates with late onset sepsis. The present study was planned in the Upgraded Department of Paediatrics (Neonatology) in Patna Medical College and Hospital, Patna from Jan 2018 to Sept 2018. Total 50 cases of new borns with signs and symptoms suggestive of sepsis with positive C-reactive protein (CRP) at or more than 72 h of postnatal age, were enrolled in the study. Neonatal meningitis is a devastating disease that requires a high index of suspicion, prompt diagnosis, and rapid treatment. While the incidence and mortality have declined with improved neonatal intensive care practices and universal adoption of preventative screening and prophylaxis programs, the associated morbidity remains unchanged. Thus, continuous monitoring of causative agents of neonatal infection, control of emergence of drug resistance among them through specific and appropriate duration of treatment, preventive intervention for transmission to the neonate can be an appropriate approach for controlling neonatal deaths.