Comparative effectiveness of antihypertensive medications was evaluated in 100 Myocardial Infarction (MI) cases (52 STEMI and 48 NSTEMI). The information of antihypertensive medications being used prior to MI event was recorded in all the patients carefully. Demographic parameters revealed high preponderance of male in STEMI cases and female preponderance was recorded in NSTEMI cases. The mean age ±SD of the STEMI and NSTEMI cases were 58.85± 11.18 and 59.83±12.84 in males and 59.44±13.3 and 60.3±10.29 years in females respectively. Analyses of number of coronary arteries involved in STEMI and NSTEMI were compared and interestingly supported the severity of disease. Single Vessel block was seen in 2:3 ratios, whereas on the contrary Triple vessel block was evident in 3:2 ratios in STEMI and NSTEMI respectively. PTCA was performed in 47 cases (46.8% STEMI & 53.2% NSTEMI) and CABG was performed in 30 cases (63.3% STEMI & 36.7% NSTEMI). Effectiveness of antihypertensive drugs revealed that Angiotensin Converting Enzyme inhibitors (ACE’I), Angiotensin Receptor Blockers (ARB) and Calcium Channel Blockers (CCB) are potent for first choice of drugs while patients on Beta Blockers (BB) ended up more frequently with TVD.