Purpose: To study the incidence and risk factors of intraoperative floppy iris syndrome (IFIS) Methods: This was a retrospective study conducted at a private hospital. Detail history and examination data were reviewed for all the patients who underwent phacoemulsification during October 2017 to March 2019. Patients were divided into IFIS and non- IFIS group. The risk factors like alpha blocker use, diabetes and hypertension were statistically analysed in the two groups. Results: 158 patients were operated during the study period. IFIS was observed in 8 patients (5.06%). Male gender (P = 0.04), hypertension (P = 0.01) and tamsulosin intake (P = <0.0001) were significant risk factors for IFIS, while the risk was not significant in diabetics (P = 0.98) and in patients on silodosin (P = 0.69). Conclusion: IFIS has a higher incidence in Indian population. Unlike tamsulosin, silodosin is not a significant risk factor. Male gender and hypertension are other significant risk factors.