5Objective: Compare two different reference cues: prompts and fixation points, grope for their event-related potential features of reaction time under three different picture stimuli types: strange picture stimuli, familiar picture stimuli and self-related picture stimuli. Methods: Tested are 35 school students. The experiment chooses commix experimental design of 3*2*2. Record kinds of brain waves the testes fulfilled separately and deal with them classified and spliced. Results: No matter the cue clew is prompts or fixation points, deceive reaction has a longer reaction time and lower veracity compared with honesty reaction. In the 400ms~550ms time zone, the amplitude of prompts is smaller than the amplitude of Fixation points. Conclusion: The amplitude of prompts is smaller than the amplitude of fixation points and deceive is smaller than honesty.