The efficacy and safety of epidural dexmedetomidine and clonidine with 0.5% levobupivacaine in patients undergoing elective lower abdominal gynaecological procedure. Methods: Sixty females of ASA physical status I and II aged 18-65 years weighing after taking due consent were blindly randomized into two treatment groups. Patients received epidural 0.5% levobupivacaine 20 ml either with of 50 μg Dexmedetomidine (Group D) or 100μg Clonidine (Group C) and the total volume of study solution was kept 21ml. Onset and duration of sensory and motor blocks, duration of analgesia, sedation and adverse effects were assessed. Results: Demographic data, surgical characteristics cardio-respiratory parameters, side-effect profile were comparable and statistically not significant in both the groups. However, sedation scores with Dexmedetomidine were better than Clonidine and turned out to be statistically significant. The onset times for sensory and motor blocks were significantly shorter in Group D as compared to Group C. The duration of analgesia and motor block was significantly longer in Group D as compared to Group C. Conclusion: Dexmedetomidine was better than Clonidine as an epidural adjuvant for providing early onset of sensory analgesia, adequate sedation with no respiratory depression and prolonged postoperative analgesia.