Aim: To evaluate the shear bond strength of three different core build up materials Glass ionomer, Zirconomer and Luxacore with Zirconia using a self-adhesive resin cement. Materials and Methodology: Thirty zirconia specimens were CAD-CAM milled with 6 mm in diameter and 10 mm in length. Core specimens were made of the same dimensions. The Zirconia specimens were luted to the core specimens using self-adhesive resin cement. These samples were tested for shear bond strength. Results: ANOVA test revealed that the P value was significant between the groups (P < 0.001). While the highest mean shear bond strength value was noted in Group 3 (16.31 MPa), the lowest value was noted in Group 1 (9.06 MPa). Conclusion: From this study, it was concluded that Composite resin core material luted with Zirconia with a self-adhesive resin cement possessed the highest shear bond strength.